NOVEL INDOLYL-CHALCONE DERIVATIVES INHIBIT A549 LUNG CANCER CELL GROWTH THROUGH ACTIVATING NRF-2/HO-1 AND INDUCING APOPTOSIS IN VITRO AND IN VIVO

Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo

Abstract Increasing evidence indicates that Nrf-2, named the nuclear factor-erythroid 2-related factor, may perform anticancer function.In this study, a series of novel substituted phenyl- (3-methyl-1H-indol-2-yl)-prop-2-en-1-one (indolyl-chalcone) derivatives were synthesized and their effects on Nrf-2 activity were observed.We found that compound

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Zoonotic risks and conservation challenges: Gastrointestinal parasites in wild mammals of Chitwan National Park, Nepal

Gastrointestinal parasites (GIPs) pose a significant threat to wildlife health and biodiversity, impacting reproductive activities, behavior, survival, and population dynamics.Identifying parasitic infections in wild animals can help to mitigate extinction risk and support conservation efforts.This study investigates the prevalence, diversity, and

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Numerical Optimization of Non-destructive Ultrasonic Testing in Identifying Defects in Composite Structure of Pine Tree Trunk

According to the properties of the pine tree trunk and its wide range of applications, finding its defects can play a vital role in reducing costs.Since the ultrasonic test is a non-destructive method, this method is an lock shock and barrel art appropriate alternative to find defects in the pine tree trunks.Optimizing the ultrasonic non-destructiv

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Representation and Immersion. The Embodied Meaning of Literature

This article explores the relations among three forms of representations (artistic, red pygmy dogwood mental, and neural) and immersion, considered as an altered state of consciousness, in the context of literary reading.We first define immersive reading as an intensification of our embodied experience of literary representation, in read more accor

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